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Jonathan Moore

Assistant Professor of Biology and Lab Coordinator

Contact Information

R. C. Seaver Biology Building, Room 108
175 W Sixth Street
Claremont, CA 91711
Seaver South, Room 128


Ph.D. University of California, Los Angeles
B.S. University of North Carolina, Chapel Hill

Professional Experience

VAssistant Professor of Biology and Lab Coordinator, Pomona College
Visting Scientist, California Inistitute of Technology
NIH NRSA Postdoctoral Fellow, California Institute of Technology
Visiting Assistant Professor, Pomona College
Research Associate, Millennium Pharmaceuticals
Research Associate, ImmunoGen

Postdoctoral Fellow, University of Colorado
Postdoctoral Fellow, University of Oregon


Biology 40: Introductory Genetics with Laboratory
Biology 41C: Introduction to Cell Chemistry & Cell Biology with Laboratory

Research Interests

The evolutionary origins of adaptive immunity - the branch of the immune system utilizing B and T cells and conferring resistance to many common infectious diseases - is largely a mystery. To examine this, we research the transcriptional control of immune genes in sea lamprey and bony fishes. Of particular interest is the control of the lamprey's VLR-B gene, a gene functionally analogous to antibody genes but with no evolutionary homology to them.

Additionally, I have a long-standing interest in mathematical biology, in particular gene-structure prediction and the use of graph theory for phylogentic trees.

Selected Publications

Rothenberg, E.V. J.E. Moore, and M.A. Yui. Launching the T-Lineage Developmental Programme. 2008. Molecular Dissection of Stem-Cell Entry into the T Lymophocyte Developmental Pathway. Nat. Rev. Immunol. 8: 9-21. [abstract]

Tydell, C.C., E.S. David-Fung, J.E. Moore, L. Rowen, T. Taghon, and E.V. Rothenberg. Molecular Dissection of Prethymic Progenitor Entry into the T Lymphocyte Developmental Pathway. J. Immunol. 179: 421-438. [abstract | full text | pdf]

Moore, J.E. and J.A. Lake. Gene Structure Prediction in Syntenic DNA Segments. Nucleic Acids Res. 31: 7271-7279. [abstract | full text | pdf]

Jain, R., M.C. Rivera, J.E. Moore, and J.A. Lake. Horizontal Gene Transfer Accelerates Genome Innovation and Evolution. Mol. Biol. Evol. 20: 1598-1602. [abstract | full text | pdf]

Lake, J.A. and J.E. Moore. Phylogenetic Analysis & Comparative Genomics. Trends Guide to Bioinformatics, a Trends Supplement 22-23. [abstract]

Rivera, M.C., R. Jain, J.E. Moore, and J.A. Lake. Genomic Evidence for Two Functionally Distinct Gene Classes. Proc. Natl. Acad. Sci. USA 95: 6239-6244. [abstract | full text | pdf]