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Lenny Seligman

Professor of Biology

Contact Information

R. C. Seaver Biology Building, Room 222
175 W Sixth Street
Claremont, CA 91711


Ph.D. University of Washington, Genetics
B.A. University of California, San Diego, Biochemistry and Cellular Biology

Professional Experience

Assistant and Associate Professor of Biology, Pomona College
Postdoctoral Fellow, University of Washington
Assistant Professor of Biology, Pacific University
Visiting Assistant Professor of Biology, Pomona College


Biology 1A: Human Genetics for Non-Majors
Biology 40: Introductory Genetics and Biology
Biology 165A: Molecular Genetics of Cancer
Biology 167: Microbial Genetics

Research Interests

Homing endonucleases are enzymes that recognize and cleave DNA target sequences of sufficient length to be unique in complex genomes and, as such, are important tools for gene targeting procedures. We utilize molecular genetic approaches to engineer homing endonucleases with unique target specificities.

Selected Publications

Rosen, L.E*, H.A. Morrison*, S. Masri*, M.J. Brown*, B. Springstubb*, D. Sussman, B.L. Stoddard, and L.M. Seligman. 2006. Homing endonuclease I-CreI derivatives with novel DNA target specificities. Nucleic Acids Res. 34: 4791-4800. [abstract | full text | pdf]

Sussman, D., M. Chadsey, S. Fauce*, S. Engel*, A. Bruett*, R. Monnat, Jr., B.L. Stoddard, and L.M. Seligman. 2004. Isolation and characterization of new homing endonuclease specificities at individual target site positions. J. Mol. Biol. 342: 31-41. [abstract]

Seligman, L.M., K. Chisholm*, B.S. Chevalier, M.S. Chadsey, S.T. Edwards, J.H. Savage, and A.L. Veillet*. 2002. Mutations altering the cleavage specificity of a homing endonuclease. Nucleic Acids Res. 30: 3870-3879. [abstract | full text | pdf]

Seligman, L.M., K.M. Stephens, J.H. Savage*, and R.J. Monnat, Jr. 1997. Genetic analysis of the Chlamydomonas reinhardtii I-Cre I mobile intron homing system in Escherichia coli. Genetics 147: 1653-1664. [abstract | pdf]

*Undergraduate co-author