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Annotated Bibliography Example

This is a sample of what was turned in by a molecular biology student as one of the references in the annotated bibliography.

Jinks-Robertson, S. Michelitch, M. Ramcharan S. Substrate length requirements for efficient mitotic recombination in Saccharomyces cerevisiae. Mol Cell Biol. 1993 Jul;13(7):3937-50

This paper seeks to determine the relationship between the length of DNA segments and the rate of homologous mitotic recombination. They discovered a linear response in segments from 960 bp down to 250 bp. However the efficiency of recombination always fell substantially at 250 bp regardless of where the repeats were positioned in the yeast genome. This phenomenon of suppressed short sequence recombination is what our project seeks to explain. Our current hypothesis is that upon formation of a double-strand break, exonucleolytic activity destabilizes DNA ends so that they cannot take part in SSR.