"Neuroimmunological Regulation of Sleep"

Dr. Audrey Chen (Dept of Neurobiology & Behavior, UC Irvine)

March 6, 2018; 5:00PM

Burns Lecture Hall (RM B31); Keck Science Center. Burns Lecture Hall is located in the basement of the W.M. Keck Science Center, which is located on the corner of N. Mills Ave. and 9th St.  Burns Lecture Hall is wheel chair accessible.

FMI: Thomas B. Borowski, Ph.D; Email: thomas_borowski@pitzer.edu; Phone: 909-607-3808

Abstract: Over 30 million Americans suffer from chronic sleep disorders such as narcolepsy and insomnia. However, despite the medical impact of sleep disorders, relatively little is known of the genetic and neuronal mechanisms that regulate sleep and wakefulness. Previous research has indicated a link between the immune system and sleep.  Chronic sleep deprivation suppresses the immune system. In addition, antihistamine drugs suppress the immune system response and induce sleep-like states.  We examined if cytokine expression differs between wild-type and zebrafish sleep mutants and whether newly identified sleep regulators modulate sleep-wake behavior through an immune-related mechanism.