Talk by Nicholas Ball, assistant professor of chemistry
Sulfonamides, sulfamides, and sulfamates are incredibly important compounds with therapeutic applications against cancer, HIV, and microbial infections. Existing strategies to make these nitrogen-based sulfur(VI) compounds are limited by the commercial availability of starting materials and harsh reactions preventing late-stage functionalization; important for drug discovery. A new form of click-chemistry, sulfur-fluoride exchange (SuFEx), is a promising new pathway to made sulfonylated products with applications in chemical biology, materials, and synthesis. However, the stability of sulfur(VI) fluorides compared to other halogen analogues present challenges for synthetic applications.
The Ball Research group focuses on the development of new sulfur-fluoride exchange (SuFEx) reactions to make important sulfonylated compounds used in drug discovery. This approach has the potential to expand libraries of drug targets thereby lowering the cost of producing pharmaceuticals. Pedagogical approaches to undergraduate research will be discussed, particularly a model that involves industrial collaborators. The discussion will center around the challenges and strategies employed that engage undergraduate students in research, promotes retention, and enables students to engage in the broader scientific community.
This lecture is part of the Pomona College Fall Faculty Lecture series.
- Pomona College
- Frank Blue Room, Frank Dining Hall
- 260 E. Bonita Avenue