Nicholas Ball, Chemistry, Faculty
Cristian Woroch, Class of 2019, Chemistry

Cristian Woroch '19

Being at the right place at the right time may be the origin of a rare collaboration between a chemistry lab in a small liberal arts college and one of the world’s leading biopharmaceutical companies. 

It all started in 2016 when Ariana Tribby ’17, a chemistry major at Pomona College at the time, presented a poster at the American Chemistry Society (ACS) National Meeting in Philadelphia. Her research, under the guidance of Chemistry Professor Nicholas Ball, caught the attention of Pfizer’s Senior Principal Scientist Dr. Christopher am Ende.

The biopharmaceutical giant was interested in Ball’s lab work using sulfonyl fluorides to make other sulfur-based molecules. Dr. am Ende was particularly interested in Ball’s work with sulfonamides.

Sulfonyl fluorides have been used in biology for decades, are valued for their stability in water and bioactivity and are now emerging as precursors for a myriad of sulfur-based compounds. According to Ball, the stability of sulfonyl fluorides are more attractive over traditional routes using sulfonamides that require reagents that have a short self-life or undesirable side reactions. The key challenge for Pomona-Pfizer collaborative study was to figure out a way to unlock the reactivity of sulfonyl fluorides for the desired reaction. 

Mark Rusznak, Class of 2018,

Mark Rusznak '18

Sulfonamides are widely prevalent in the pharmaceutical and agrochemical industries. They represented 15 percent of the top 100 most prescribed drugs, with therapeutic applications against cardiovascular, infectious and neurological diseases in 2016.

This mutual interest between Pfizer and the Ball Lab led to a year-long research partnership to develop a methodology to make sulfonamides from sulfonyl fluorides using calcium salts. Pfizer did the initial work to come up with a sketch for a synthetic route, while Ball’s lab work involved optimizing that synthetic route and testing its versatility. After countless hours in the lab–both at Pfizer and at Pomona–many teleconference calls and more than 100 chemical reactions later, the research team had found an optimal reaction by the end of the summer of 2017. 

The study was recently published as an open access article in Organic Letters, one of the most highly-regarded academic journals in organic chemistry. Their work will hopefully translate into more efficient ways to make a diverse array of sulfonamides, key for discovering new drug targets.

Ryan Franzese, Class of 2019

Ryan Franzese '19

The article’s authors include five Pomona students who worked with Ball: Cristian Woroch ’19, Mark Rusznak ’18, Ryan Franzese ’19, Sarah Etuk ’19 and Sabrina Kwan ’20, who are a mixture of chemistry and neuroscience majors. On Pfizer’s side, along with am Ende, the research and article author team includes scientists and medical chemists: Paramita Mukherjee, Matthew Reese, Joseph Tucker, John Humphrey, who work in Pfizer’s Worldwide Research and Development division. Leah Cleary of Ideaya Biosciences was also part of the team. 

Industry Experience Vital for Chemistry Students

According to ACS data from 2013, 53 percent of chemistry graduates are employed in industry sectors after attending graduate school, while 39 percent go to work in academia. 

Sarah Etuk, Class of 2019

Sarah Etuk '19

For Ball, the goal for students in his lab is to learn how to turn theory into practice, to critically work through scientific challenges and to understand and take ownership of their work. With this Pfizer study, Pomona students were able to better understand the applications of pharmaceutical and medicinal chemistry.

My experience with industry wasn’t until I was on the job market,” says Ball. “I was never exposed to the fantastic science that is occurring at these companies or realized that it was a career possibility. My hope is that this collaboration shows students that there are other options for the them with a science degree other than academia.”

Woroch, who was second author in the study, worked closely with both Ball and Pfizer’s am Ende. This project had such an influence on Woroch’s research interests that he is continuing to pursue the topic for his senior thesis, and am Ende will be a second reader for it. 

Sabrina Kwan, Class of 2020

Sabrina Kwan '20

“What I am most excited for is an opportunity to answer questions that have been popping up since the project began,” says Woroch. “Since our collaboration started over a year ago, there has been a clear direction for the research and so when tangentially-related issues arose, I couldn't address them. Now, I can revisit them and find an entirely new project that is derived from my interests. Dr. am Ende is a very talented scientist and will be a great guide to help me do meaningful and interesting research.”

Woroch adds that the ability to apply science to real world problems is a big part of what drew him to research. “Particularly when projects are challenging or frustrating, having a practical application for your work is a driving force,” he says.

Besides this research study, Ball, am Ende and Woroch share another commonality: They all received a Beckman Scholarship at some point in their chemistry research careers. The Beckman Foundation provides grants to researchers and non-profit research institutions in chemistry and life sciences to promote scientific discoveries and to foster the invention of methods, instruments and materials that will open up new avenues of research.

I am very excited that our collaboration with Dr. am Ende’s group at Pfizer is continuing,” says Ball. “We already have a follow-up [study] to this recent paper underway. During my first conversation with Dr. am Ende, he stated that we should be working together versus working against each other and I couldn’t agree more! It is even more special that we share the bond of being Beckman Scholars.”