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Adam M. Bailis

Affiliated Visiting Scholar; Associate Dean of Professional Development, and Associate Professor of Molecular and Cellular Biology, Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope
With Pomona Since: 2019
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  • Expertise

    Expertise

    Adam Bailis studies the genetic and molecular control of genome stability in eukaryotes using the budding yeast Saccharomyces cerevisiae as a model system. His work has uncovered several of the mechanisms that permit the maintenance of genome structure following exposure to radiation and toxic chemicals. These findings are being translated into the development of the next generation of targeted cancer therapeutics.

    Areas of Expertise

    • Transmission genetics
    • Cancer Genetics
    • Genome Dynamics
    • DNA Repair
    • Homologous Recombination
    • Drug Discovery
  • Work

    Work

    With Ding, Adamson, Steele, John, Tomlinson, and Neuhausen, “Discovery of mutations in homologous recombination genes in African-American women with breast cancer,” Fam. Cancer 17, 187-195, 2018

    With Manthey, Clear, Liddell and Negritto, “Homologous recombination in budding yeast expressing the human RAD52gene reveals a Rad51-independent mechanism of conservative double-strand break repair,” Nucleic Acids Res. 45, 1879-1888, 2017

    With Clague, Wilhoite, Adamson, Weitzel and Neuhausen, “RAD51C germline mutations in breast and ovarian cancer cases from high-risk families,” PLoS One 6: e25632, 2011

    With Manthey, “Rad51 inhibits translocation formation by non-conservative recombination in Saccharomyces cerevisiae,” PLoS One 5: e111889, 2010

    With Meyer, “Telomerase deficiency affects the formation of chromosomal translocations by homologous recombination in Saccharomyces cerevisiae,” PLoS One 3: e3318, 2008

    With Pannunzio and Manthey, “RAD59 is required for efficient repair of simultaneous double-strand breaks resulting in translocations in Saccharomyces cerevisiae,” DNA Repair 7: 788-800, 2008

    With Negritto, Wu, Kuo, and Chu, “Influence of DNA sequence identity on efficiency of targeted gene replacement,”Mol. Cell. Biol. 17: 278-286, 1997

    With Rothstein, “A defect in mismatch repair in Saccharomyces cerevisiae stimulates ectopic recombination between homologous genes by an excision repair dependent process,” Genetics 126: 535-547, 1990

  • Education

    Education

    Ph.D.
    Albert Einstein College of Medicine, Yeshiva University

    B.A.S.
    University of Delaware

  • Awards & Honors

    Awards & Honors

    City of Hope, Graduate School Excellence in Teaching Award, 2002 and 2003

    Member of National Institutes of Health Study Sections, 2003–2005, 2013–present

    National Institutes of Health, NIGMS, R01, 1998-2013

    Department of Defense, 2008-2010

    National Institutes of Health Postdoctoral Fellowship, 1987

    National Institutes of Health Graduate Student Fellowship, 1985

    University of South Carolina, Taber Outstanding Graduate Student Fellowship, 1982

    University of Delaware, Degree with Honors and Distinction, 1982