Cristina "Tina" Negritto

Director and Associate Professor of Molecular Biology; Coordinator of Molecular Biology
  • Expertise


    Cristina Negritto studies genome maintenance mechanisms, particularly mechanisms involved in the repair of double strand breaks and how these can affect genome instability.

    Research Interests

    Genome maintenance mechanisms

    Areas of Expertise


    • Yeast genetics and molecular biology
    • DNA repair
  • Work


    Negritto, M. C. (2010) "Repairing Double-Strand DNA Breaks," Nature Education 3(9):26

    Salim, H. M., Negritto M. C, Cavalcanti, A. R. (2009). "1+1 = 3: a fusion of 2 enzymes in the methionine salvage pathway of Tetrahymena thermophila creates a trifunctional enzyme that catalyzes 3 steps in the pathway." PLoS Genet 5(10): e1000701.

    Maria Cristina Negritto and Glenn Manthey. Overview of Blotting” Current Protocols Essential Laboratory Techniques (John Wiley & Sons, Inc. 2008), 8.1.1-8.1.19

    Negritto, M.C, J. Qiu, D.O. Ratay, B. Shen, and A.M. Bailis. 2001. Novel function of Rad27 (FEN-1) in restricting short-sequence recombination. Mol. Cell. Biol. 21: 2349-2358.

    Maines, S., M.C. Negritto, X. Wu, G.M. Manthey, and A.M. Bailis. 1998. Novel mutations in the RAD3 and SSL1 genes perturb genome stability. Genetics 150: 963-976.

    Negritto, M.C., X. Wu, T. Kuo, S. Chu, and A.M. Bailis. 1997. Influence of DNA sequence identity on efficiency of targeted gene replacement. Mol. Cell. Biol. 17: 278-286.

    Bailis, A.M., S. Maines, and M.C. Negritto. 1995. The essential helicase gene RAD3 suppresses short-sequence recombination in Saccharomyces cerevisiae. Mol. Cell. Biol. 15: 3998-4008.

  • Education


    Beckman Research Institute of the City of Hope National Medical Center


    Licenciada, Facultad de Ciencias exactas y Naturales
    ​Universidad de Buenos Aires, Argentina

    Recent Courses Taught

    • Biochemistry and Molecular Biology of DNA Repair
    • Human Diseases with Defective Genome Maintenance Mechanisms
    • Molecular Biology with Lab
  • Awards & Honors

    Awards & Honors

    Pomona College, Wig Distinguished Professor Award for Excellence in Teaching, 2013