Jon Moore

Laboratory Coordinator and Associate Professor of Biology
With Pomona Since: 2012
  • Expertise


    Jonathan Moore studies how the adaptive immune system—the branch of immunity utilizing B and T cells and conferring resistance to many common infectious diseases—evolved to be. To this end, he examines the similarities and differences in the genetic regulation of immune genes in sea lamprey and bony fishes. Of particular interest is a lamprey gene functionally like antibody genes but with no evolutionary relationship to them.

    Additionally, Jon has an abiding interest in mathematical biology and bioinformatics. In particular, he has worked in gene structure prediction, the prediction of genetic regulatory elements, the use of graph theory in the study of evolution, and horizontal gene transfer.

    Research Interests

    • Evolutionary origins of adaptive immunity
    • Mathematical biology

    Areas of Expertise


    • Transcriptional Regulation
    • Molecular Evolution
    • Immunology
    • Bioinformatics
  • Work


    Rothenberg, E.V. J.E. Moore, and M.A. Yui. Launching the T-Lineage Developmental Programme. 2008. Molecular Dissection of Stem-Cell Entry into the T Lymphocyte Developmental Pathway. Nat. Rev. Immunol. 8: 9-21.

    Tydell, C.C., E.S. David-Fung, J.E. Moore, L. Rowen, T. Taghon, and E.V. Rothenberg. Molecular Dissection of Prethymic Progenitor Entry into the T Lymphocyte Developmental Pathway. J. Immunol. 179: 421-438.

    Moore, J.E. and J.A. Lake. Gene Structure Prediction in Syntenic DNA Segments. Nucleic Acids Res. 31: 7271-7279.

    Jain, R., M.C. Rivera, J.E. Moore, and J.A. Lake. Horizontal Gene Transfer Accelerates Genome Innovation and Evolution. Mol. Biol. Evol. 20: 1598-1602.

    Lake, J.A. and J.E. Moore. Phylogenetic Analysis & Comparative Genomics. Trends Guide to Bioinformatics, a Trends Supplement 22-23.

    Rivera, M.C., R. Jain, J.E. Moore, and J.A. Lake. Genomic Evidence for Two Functionally Distinct Gene Classes. Proc. Natl. Acad. Sci. USA 95: 6239-6244.

  • Education


    University of California, Los Angeles

    Bachelor of Science
    University of North Carolina, Chapel Hill

    Recent Courses Taught

    • Introductory Genetics with Lab
    • Introduction to Cell Chemistry & Cell Biology with Lab