Lenny M. Seligman

John P. and Magdalena R. Dexter Professor of Biology; On leave Spring 2024
  • Expertise


    Lenny Seligman specializes in the use of molecular genetic approaches to engineer homing endonucleases with unique target specificities. Since these enzymes recognize and cleave DNA target sequences of sufficient length to be unique in complex genomes, they represent very powerful tools for genetic engineering.

    Areas of Expertise


    • Molecular Genetics
    • Microbial Genetics
    • Structure and Function of Protein/DNA Interactions


  • Work


    With Stephens, Savage and Monnat, "Genetic Analysis of the Chlamydomonas Reinhardtii I-CreI Mobile Intron Homing System in Escherichia coli," Genetics 147, 1653-1664, 1997

    With Bailey and Manoil, "Sequences Determining the Cytoplasmic Localization of a Chemoreceptor Domain," J. Bacteriol. 177: 2315-2320, 1995

    With Susman, Chadsey, Fauce, Engel, Bruett, Monnat, and Stoddard, "Isolation and Characterization of New Homing Endonuclease Specificities at Individual Target Site Positions," Journal of Molecular Biology, 342, 31-41, 2004

    With Manoil, "An Amphipathic Sequence Determinant of Membrane Protein Topology," J. Biol. Chem. 269: 1988-1996, 1994

    With Chisholm, Chevalier, Chadsey, Edwards, Savage, and Veillet, "Mutations Altering the Cleavage Specificity of a Homing Endonuclease," Nucleic Acids Res., 30, 3870-3879, 2002

  • Education


    University of Washington

    Bachelor of Arts
    University of California, San Diego

    Recent Courses Taught

    • Independent Research in Biology
    • Introductory Genetics with Lab
    • Microbial Genetics with Lab
    • Molecular Genetics of Cancer
    • Independent Research in Molecular Biology
  • Awards & Honors

    Awards & Honors

    Pomona College, Wig Distinguished Professorship Award for Excellence in Teaching, 2000

    National Science Foundation, Graduate Fellowship, 1987

    Phi Beta Kappa, 1985